Negative pressure pulmonary edema after laparoscopic cholecystectomy: A case report and literature review

Rationale: Negative pressure pulmonary edema (NPPE) is an acute onset of non-cardiogenic interstitial pulmonary edema, commonly seen among surgical patients after extubation from general aneasthesia. It is mainly caused by rapid inspiration with acute upper airway obstruction resulting in significant negative thoracic pressure. Patient concerns: A 24-year-old female patient who underwent laparoscopic cholecystectomy under general anesthesia and developed NPPE postoperatively. Diagnoses: Her main clinical manifestation was coughing up pink foamy sputum; postoperative CT showed increased texture in both lungs and bilateral ground glass opacities. Interventions: Diuretics and steroids were used, and symptomatic supportive treatments such as oxygen were given. Outcomes: After treatment, on the fourth post-operative day, her symptoms were relieved and her vital signs were stable enough for her to be discharged. Lessons: Although this is a rare and severe complication, the prognosis of NPPE is good when it is managed with proper diagnosis and treatment.


Introduction
[3] This is a very rare complication in patients after general anesthesia.According to previous case reports, NPPE often occurs in young, healthy patients. [2,4,5]n this review, we report on a 24-year-old female patient who underwent laparoscopic cholecystectomy under general anesthesia and developed NPPE postoperatively.So, we describe the patient clinical symptoms and associated treatment measures.

Case report
The patient, a 24-year-old Chinese female, started to suffer from right upper abdominal pain after eating 6 months ago, with many recurrent episodes, which was treated with Ursodeoxycholic Acid Capsules to no avail.After several ultrasounds, which indicated that the gallbladder stones were increasing in size, she went to the hospital for a cholecystectomy.She had no clinical symptoms other than right upper abdominal pain, no history of "hypertension," "congenital heart disease," or other diseases, and no history of previous surgery.

Physical examination
She is a well-developed young woman with no disease other than gallbladder stones.She was 155 cm tall and weighed 49.5 kg with a BMI of 20.60 kg/m 2 .On admission, vital signs were stable, Temperature: 36.5°C;Pulse: 68 beats/minutes; Respiration: 17 breaths/minutes; Blood pressure: 110/68 mm Hg.On palpation, there was mild deep-pressure pain in the right upper abdomen, without rebound tenderness or muscle tension.

Diagnostic testing
Six months before surgery, the ultrasound showed gallbladder stones testing about 0.4 cm; 3 months later, about 0.7 cm, and The authors have no funding and conflicts of interest to disclose.
The datasets generated during and/or analyzed during the current study are available from the corresponding author on reasonable request.
The studies involving human participants were reviewed and approved by the People Hospital of Lezhi.The patients provided their written informed consent to participate in this study.Written informed consent was obtained from the individual(s) for the publication of any potentially identifiable images or data included in this article.
before admission, about 1 cm.Preoperative cardiac ultrasound and chest X-ray were completed and showed no significant abnormalities; laboratory tests were not found to be substantial (Table 1).

Hospital course
According to the standards of the American Society of Anesthesiologists (ASA), she had an ASA I. Dexmedetomidine was continuously pumped at 0.25 µg/kg/h, Midazolam 2 mg, sufentanil 15 µg, propofol 120 mg, and vecuronium bromide 5 mg were administered successively.After tracheal intubation, 2% sevoflurane was continuously inhaled, and remifentanil was continuously pumped at 0.05 µg/kg/min.An additional intraoperative dose of sufentanil 5 µg was administered, followed by neostigmine 1 mg, flumazenil 0.5 mg, and atropine 0.5 mg at the end of the procedure.When the patient was conscious, the endotracheal tube was removed.The entire procedure lasted approximately 1 hour, the anesthesia lasted 71 minutes, the intraoperative fluid volume was 400 mL, and the bleeding volume was about 5 mL.The urine volume was not recorded because a urinary catheter was not placed in place before the operation.During the procedure, all the vital signs were stable, and no abnormalities were observed.
She was admitted to the post-anesthesia care unit for 30 minutes and was transferred to the general ward as she did not show any clinical symptoms during the observation.Twenty minutes later, the patient began to cough pink frothy sputum, while diffuse wet rales could be heard on auscultation of both lungs.The patient further developed sinus tachycardia with a pulse range of between 122 beats/minutes and 130 beats/ minutes.SpO 2 dropped to 80% to 90% with the nasal cannula with oxygen flow at 3 L/minutes, respiratory rate was 20 to 25 breaths/minutes, and no symptoms such as respiratory distress were observed.Blood pressure was within the normal range of 100 to 115/70 to 75 mm Hg.An arterial blood gas analysis was immediately completed and revealed PaCO 2 of 45 mm Hg, PaO 2 of 61 mm Hg, and SaO 2 of 90% (Table 2).The possibility of pulmonary edema was considered.After consultation with the cardiology, respiratory and anesthesiology departments, we initially ruled out the diagnosis of cardiogenic pulmonary edema and considered the diagnosis of NPPE because of the patient previous good physical condition and the approximately normal preoperative laboratory indices and imaging findings.Treatment was started with a 20 mg furosemide diuretic, and a urinary catheter was placed to record urine output, followed by 3 days of treatment with methylprednisolone sodium succinate 80 mg to prevent progression of the disease.Because the patient oxygen saturation could be maintained at about 90, we only administered mask oxygen without tracheal intubation and ventilator-assisted therapy.
With the above treatment, her cough improved on the first day after surgery and her sputum was white mucus sputum instead of pink foamy sputum.A chest CT was also completed on the morning of the first postoperative day, showing increased texture in both lungs and bilateral ground glass opacities (Fig. 1).And some important laboratory parameters were also repeated and no relevant clinically significant abnormalities were found (Table 1).Due to the relief of her cough symptoms, diuretics were discontinued on the second postoperative day, but treatment with methylprednisolone was continued and maintained until the second postoperative day in order to continue to reduce respiratory edema and antiinflammatory therapy.After discontinuation of the medication, the patient vital signs were stable and she was therefore discharged on the fourth postoperative day.At follow-up, no further relevant chest radiographs or CTs were done because the patient was preparing for pregnancy.

Discussion
NPPE is a rare and severe but completely curable form of non-cardiogenic pulmonary edema.Among patients undergoing surgical procedures, it is commonly seen as an acute upper airway obstruction following extubation under general anesthesia.The radiological manifestation of NPPE due to upper airway obstruction was first reported in 1973. [6]According to studies, the factors that trigger the development of NPPE can be grouped into 2 categories: one is acute upper airway obstructive factors, including contractures of airway smooth muscle (e.g., laryngospasm), compression (tumor compression, inflammatory edema compression, tissue compression, and foreign body compression); and the other is caused by chronic obstructive diseases, mostly seen in sleep apnea syndrome, tonsillar and adenoidal hypertrophy. [2,7,8]0][11] The most important factor causing NPPE is the rapid generation of a large negative pressure in the thoracic cavity during suctioning (Müller maneuver) of the obstructed voice box, which causes significant negative thoracic pressure. [12,13]he main manifestation is that some patients take one or several deep breaths violently during general anesthesia awakening, and the laryngeal edema caused by tracheal intubation is blocked, leading to acute upper airway obstruction.The normal human chest pressure is −2 to −5 cmH 2 O, but in cases of severe acute upper airway obstruction, the pressure can reach −100 cmH 2 O. [8] Inspiratory airway obstruction and vigorous respiratory motion are thought to be the 2 main factors contributing to NPPE.The main determinants  of the rate of pulmonary edema formation are the transvascular hydrostatic pressure, the protein osmolarity gradient, and vascular permeability.When the rate of interstitial fluid accumulation exceeds the capacity of lymphatic drainage, pulmonary edema may develop, as evidenced by decreased arterial oxygen saturation, coughing up pink foamy sputum, or the appearance of new opacities on chest radiographs. [8,12]t has also been suggested that hypoxia and increased capillary hydrostatic pressure might lead to rupture of alveolar capillaries and disruption of barrier function, leading to an increase in their permeability and contributing to the formation of pulmonary edema. [13]ccording to studies, common risk factors for the development of NEEP after surgery included younger patients, males, ASA grade I to II, difficult intubation, head and neck surgery, obesity, and patients with history of recent respiratory infections. [2,4,5]In adults, young and healthy males were more likely to produce greater inspiratory force, which could induce extremely high negative intrathoracic pressure when upper airway obstruction developed due to laryngospasm can be explained by "post-extraction vocal occlusion." [2,14]eanwhile, elderly patients were often unable to generate sufficient negative chest pressure to develop pulmonary edema. [8]In the pediatric population, the most common cause of obstruction is subglottic obstruction due to acute infectious laryngitis or epiglottitis. [12]n most reported cases, NEEP usually occurs quickly, with only a few minutes between the onset of airway obstruction and the onset of pulmonary edema symptoms. [13]The most common clinical presentation of patients with NPPE is frothy pink sputum from the mouth or tracheal tube and wet rales on auscultation of both lungs.Severe cases may present with progressive dyspnea and cyanosis, and hypoxia.A chest X-ray usually shows bilateral alveolar infiltrates or interstitial opacification, while CT mainly shows bilateral ground glass opacities. [8]In this case, however, the patient first presented with coughing pink foamy sputum about 20 minutes after being taken out of the post-anesthesia care unit.It was the patient frequent coughing up of this sputum that drew our attention, and after consultation with the relevant departments, we began targeted treatment.
If properly treated, most patients with NPPE will have a resolution of pulmonary edema signs within 12 to 48 hours, [14] with a small number resolving within 4 hours. [15]Relief of expiratory obstruction is necessary, probably because when the acute upper airway obstruction is resolved, the negative pressure in the pleural cavity begins to decrease, exudation continues to decrease, some of the accumulated fluid is coughed up as sputum, and some is reabsorbed via lymphatic reflux, gradually reducing the signs of pulmonary edema. [14]ow-tidal-volume ventilation may be beneficial.Although the area which has not been deeply studied was about ventilation for NPPE patients, a meta-analysis found a beneficial effect of low tidal volume ventilation on both the development of lung injury and mortality. [12,16]However, in this case, the airway tended to become obstructed due to the Mueller maneuver.Hence, as the patient developed spontaneous breathing, the obstruction improved, and there was no need for reintubation with assisted mechanical ventilation as is the case in most NPPE patients.
In addition, the use of diuretics and steroids remains controversial, but both are commonly used in the treatment of patients with pulmonary edema.Some believe that NPPE is noncardiogenic pulmonary edema and that the use of diuretics is of little use. [14]Others recommend the use of small doses of diuretics.This is because they believe that it reduces blood volume and lowers pulmonary capillary pressure in the presence of normal renal function. [12,17]Therefore, we used diuretics in the course of treatment.Although the use of steroids is controversial, we used it during treatment.This is because steroids have the following effects: reduce the inflammatory response and decrease capillary permeability; improve ventilation by relieving bronchospasm and decreasing intra-alveolar pressure; and promote diuresis by increasing renal blood flow and decreasing secretion of aldosterone and diuretic hormone.Therefore, in the treatment of this patient, we used methylprednisolone.Also, some researchers have suggested the addition of β agonists.Although NPPE may not be caused by bronchospasm, studies have shown that it can promote fluid clearance from the alveoli, thereby relieving the symptoms of pulmonary edema. [12,14]Whereas in this patient, we did not use it.This was because the patient symptoms gradually started to improve after the use of diuretics and steroids and oxygen therapy.

Conclusion
NPPE is an acute onset of non-cardiogenic interstitial pulmonary edema.Its treatment remains an empirical one, as there is no consensus on its treatment and it is a rare postoperative complication of general anesthesia.We described our treatment course and provide one of our treatment strategies: in the presence of stable vital signs, oxygen can be administered by mask or nasal cannula (without the use of mechanical ventilation), combined with diuretics and steroid medication.

Figure 1 .
Figure 1.(A and B) Patient preoperative chest radiograph, no significant abnormality; (C and D) patient chest CT after NPPE, massive patchy hyperdense shadow in both lungs.NPPE = negative pressure pulmonary edema.

Table 1
Relevant laboratory indicators before and after the onset of NPPE.

Table 2
Arterial blood gas (ABG) results after the onset of NPPE.